Hypoxia is Involved in Deep Tissue Injury Formation in a Rat Model

Publons ID(not set)
Wos IDWOS:000274833000006
Doi
TitleHypoxia is Involved in Deep Tissue Injury Formation in a Rat Model
First Author
Last Author
AuthorsSari, Y; Nagase, T; Minematsu, T; Akase, T; Nakagami, G; Sanada, H; Sugama, J;
Publish DateFEB 2010
Journal NameWOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
Citation9
AbstractPressure ulcers that develop from deep tissue are known as deep tissue injuries (DTI). Although several mechanisms, including ischemic hypoxia, are attributed to pressure ulcer formation, the mechanisms involved in DTI formation are still unclear. Previous studies have suggested that hypoxia is involved in DTI in vitro, but it has yet to be determined whether hypoxia is also involved in DTI in vivo. Therefore, this study aimed to investigate whether hypoxia is involved in DTI using a newly established DTI model. Rats were divided into control, low pressure DTI, and high pressure DTI groups. Results of wound healing tests indicated that more severe DTI resulted in prolonged healing time, more severe inflammation and muscle damage, higher levels of exudate creatine phosphokinase, and greater muscle edema. Increased hypoxia was observed in severe DTI-nuclear localization of hypoxia-inducible factor-1 alpha was markedly increased in the high pressure DTI group, while the low pressure group showed more increased cytoplasm localization compared to the control group on day 3. Study results revealed that hypoxia is involved in DTI in vivo.
Publish TypeJournal
Publish Year2010
Page Begin44
Page End51
Issn1044-7946
Eissn1943-2704
Urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:000274833000006
AuthorProf. YUNITA SARI, S.Kep., Ns., MHS., Ph.D
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