| Publons ID | 4140062 |
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| Wos ID | WOS:000281576500016 |
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| Doi | 10.1016/j.jpba.2010.07.030 |
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| Title | Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin |
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| First Author | |
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| Last Author | |
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| Authors | Hermawan, D; Ibrahim, WAW; Sanagi, MM; Aboul-Enein, HY; |
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| Publish Date | DEC 15 2010 |
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| Journal Name | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS |
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| Citation | 25 |
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| Abstract | A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) method with hydroxypropyl-gamma-cyclodextrin (HP-gamma-CD) as chiral selector for the enantiomeric separation of econazole is reported. Enantioseparation of econazole was successfully achieved by the optimized CD-MEKC system containing 40 mM HP-gamma-CD, 50 mM SDS and 20 mM phosphate buffer (pH 8) solution with an analysis time of less than 9 min Calibration curves were linear for the two stereoisomers of econazole (r(2) > 0.998). Good repeatabilities in the migration time, peak area and peak height were obtained in terms of RSD% ranging from 030 to 7 67%. Combination of solid-phase extraction (SPE) procedure using diol column and the CD-MEKC method was successfully applied to the determination of econazole in a formulated cream sample (C) 2010 Elsevier B V All rights reserved |
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| Publish Type | Journal |
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| Publish Year | 2010 |
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| Page Begin | 1244 |
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| Page End | 1249 |
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| Issn | 0731-7085 |
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| Eissn | 1873-264X |
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| Url | https://www.webofscience.com/wos/woscc/full-record/WOS:000281576500016 |
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| Author | DADAN HERMAWAN, S.Si, M.Si, Ph.D |
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| File | 55699.pdf |
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