| Publons ID | 4140058 |
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| Wos ID | WOS:000273591600027 |
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| Doi | |
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| Title | Comparison of Signal-to-Noise, Blank Determination, and Linear Regression Methods for the Estimation of Detection and Quantification Limits for Volatile Organic Compounds by Gas Chromatography |
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| Last Author | |
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| Authors | Sanagi, MM; Ling, SL; Nasir, Z; Hermawan, D; Ibrahim, WAW; Abu Naim, A; |
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| Publish Date | NOV-DEC 2009 |
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| Journal Name | JOURNAL OF AOAC INTERNATIONAL |
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| Citation | 96 |
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| Abstract | LOD and LOQ are two important performance characteristics in method validation. This work compares three methods based on the International Conference on Harmonization and EURACHEM guidelines, namely, signal-to-noise, blank determination, and linear regression, to estimate the LOD and LOQ for volatile organic compounds (VOCs) by experimental methodology using GC. Five VOCs, toluene, ethylbenzene, isopropyl benzene, n-propylbenzene, and styrene, were chosen for the experimental study. The results indicated that the estimated LODs and LOQs were not equivalent and could vary by a factor of 5 to 6 for the different methods. It is, therefore, essential to have a clearly described procedure for estimating the LOD and LOQ during method validation to allow interlaboratory comparisons. |
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| Publish Type | Journal |
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| Publish Year | 2009 |
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| Page Begin | 1833 |
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| Page End | 1838 |
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| Issn | 1060-3271 |
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| Eissn | 1944-7922 |
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| Url | https://www.webofscience.com/wos/woscc/full-record/WOS:000273591600027 |
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| Author | DADAN HERMAWAN, S.Si, M.Si, Ph.D |
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| File | 55695.pdf |
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