| Publons ID | 37934037 |
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| Wos ID | WOS:000218823100005 |
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| Doi | 10.11113/mjfas.v10n4.277 |
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| Title | Optimum Conditions For The Synthesis of High Solubility Carboxymethyl Chitosan |
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| First Author | Kurniasih, Mardiyah; Purwati; Hermawan, Dadan; Zaki, Muhamad; |
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| Last Author | |
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| Authors | Kurniasih, M; Purwati; Hermawan, D; Zaki, M; |
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| Publish Date | OCT-DEC 2014 |
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| Journal Name | MALAYSIAN JOURNAL OF FUNDAMENTAL AND APPLIED SCIENCES |
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| Citation | 4 |
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| Abstract | A research on optimizing the synthesis conditionsto obtaincarboxymethyl chitosan with the highest solubility in 1%(v/v) acetic acid as a solvent have been performed. Optimization was performed by varying: the concentration of NaOH during alkalizing the chitosan, chitosan: monochloroacetic acidratio, temperature and reaction time. This study uses a full factorial experimental design. The results showed that the highest solubility was found in 40% (w/v) NaOH concentration, chitosan to monochloroacetic acid ratio of 1: 7, reaction temperature of 80 degrees C and reaction time at 4 hours with the solubility up to 63.78 mg /mL. The IR and NMR (H-1 and C-13) spectra confirmed the success of the synthesis. The results of water content, ash content, molecular weight and swelling effect of carboxymethyl chitosan at the highest solubility were 14.27%, 8.48%, 2.8678 x 10(5) g/mol and 884.19%, respectively. |
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| Publish Type | Journal |
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| Publish Year | 2014 |
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| Page Begin | 189 |
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| Page End | 194 |
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| Issn | 2289-5981 |
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| Eissn | 2289-599X |
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| Url | https://www.webofscience.com/wos/woscc/full-record/WOS:000218823100005 |
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| Author | MARDIYAH KURNIASIH, S.Si, M.Sc. |
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| File | 17043.pdf |
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