| Publons ID | 28146664 |
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| Wos ID | WOS:000514098900001 |
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| Doi | 10.1002/slct.201903168 |
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| Title | Biotransformation of Host Plant Flavonoids by the Fungal Endophyte Epicoccum nigrum |
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| First Author | Harwoko, Harwoko; Hartmann, Rudolf; Daletos, Georgios; |
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| Last Author | Proksch, Peter |
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| Authors | Harwoko, H; Hartmann, R; Daletos, G; Ancheeva, E; Frank, M; Liu, Z; Proksch, P; |
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| Publish Date | DEC 6 2019 |
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| Journal Name | CHEMISTRYSELECT |
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| Citation | 3 |
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| Abstract | Fermentation of the fungus Epicoccum nigrum isolated from leaves of Salix sp. on green lentil solid medium yielded the flavonol kaempferol (3) as well as two kaempferol O-diglyco-sides (1 and 2) including the new compound 1. The fungal flavonoids bear strong structural similarities to kaempferol derivatives such as kaempferol O-glycoside (4) being present in green lentils. Furthermore, feeding experiments were conducted by adding flavonoids (kaempferol and rutin) as precursors to solid rice media followed by HPLC and LC-MS analyses. Fermentation of the fungus on flavonoid free solid rice medium afforded flavonoid free extracts indicating that the fungal flavonoids originate through hydrolytic cleavage of kaempferol glycosides such as 4 followed by glycosylation and acetylation. This study suggests that E. nigrum is capable of biotransformation reactions of plant derived flavonoids whereas de novo biosynthesis of flavonoids is less likely. |
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| Publish Type | Journal |
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| Publish Year | 2019 |
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| Page Begin | 13054 |
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| Page End | 13057 |
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| Issn | 2365-6549 |
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| Eissn | |
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| Url | https://www.webofscience.com/wos/woscc/full-record/WOS:000514098900001 |
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| Author | Dr.rer.nat. Apt HARWOKO, S.Farm, M.Sc. |
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| File | 16694.pdf |
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