| Publons ID | 36612334 |
|---|
| Wos ID | WOS:000447682100020 |
|---|
| Doi | 10.1016/j.ijbiomac.2018.07.038 |
|---|
| Title | Carboxymethyl chitosan as an antifungal agent on gauze |
|---|
| First Author | Kurniasih, Mardiyah; Purwati; Cahyati, Thika; Dewi, Ratna Stia; |
|---|
| Last Author | |
|---|
| Authors | Kurniasih, M; Purwati; Cahyati, T; Dewi, RS; |
|---|
| Publish Date | NOV 2018 |
|---|
| Journal Name | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES |
|---|
| Citation | 53 |
|---|
| Abstract | Chitosan is a biopolymer that has antifungal activity against C. albicans. Chemical modification of chitosan can provide it with new functional properties for a wide range of biological and biomedical applications. Carboxymethyl chitosan is a derivative of chitosan obtained by etherification of alkaline chitosan with monochloroacetic acid. Carboxymethyl chitosan has a higher solubility than chitosan; therefore it is more readily applicable for use in various fields. Chitosan also has antifungal activity against C. albicans. This study evaluated carboxymethyl chitosan as a gauze-coating material to be used for its antifungal properties. This study also optimized the coating process. Gauze was coated with carboxymethyl chitosan then characterized by Fourier Transform Infra-Red Spectrophotometer (FTIR), X-ray diffraction and scanning electron microscopy (SEM). The antifungal activities of gauze-coated samples were then tested by the diffusion method. The results show that the optimum conditions for the process of coating gauze with carboxymethyl chitosan are dipping ten times at a concentration of 1% for 50 s. Antifungal activities of carboxymethyl chitosan-coated gauze as measured by the diameter of the growth inhibition area are 0.30 cm higher than chitosan-coated gauze, which has a growth-inhibition diameter of 0.12 cm. (C) 2018 Elsevier B.V. All rights reserved. |
|---|
| Publish Type | Journal |
|---|
| Publish Year | 2018 |
|---|
| Page Begin | 166 |
|---|
| Page End | 171 |
|---|
| Issn | 0141-8130 |
|---|
| Eissn | 1879-0003 |
|---|
| Url | https://www.webofscience.com/wos/woscc/full-record/WOS:000447682100020 |
|---|
| Author | Dr RATNA STIA DEWI, S.Si, M.Sc. |
|---|
| File | 13406.pdf |
|---|