| Publons ID | (not set) |
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| Wos ID | WOS:000996215400001 |
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| Doi | 10.1007/s10068-023-01343-9 |
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| Title | Formation of dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides from Jack Bean (<i>Canavalia ensiformis</i> (L.) DC.) sprout in simulated digestion |
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| First Author | |
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| Last Author | |
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| Authors | Agustia, FC; Supriyadi; Murdiati, A; Indrati, R; |
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| Publish Date | MAY 29 2023 |
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| Journal Name | FOOD SCIENCE AND BIOTECHNOLOGY |
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| Citation | |
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| Abstract | Bean sprouts are potential plant proteins that produce DPP-IV inhibitory peptides. These peptides must be stable and active in the brush border membrane of the small intestine to inhibit DPP-IV. The purpose of this research is to evaluate the DPP-IV inhibitory activity of jack bean sprouts using pepsin-pancreatin during simulated digestion, as well as the absorption of these peptides through the everted gut sac method. The results showed that after 180 min of digestion simulation, the Mw < 1 kDa peptide fraction of jack bean hydrolysate, which germinated for 60 h (HG60), had the highest inhibitory activity. The duodenum absorbs most of the peptides with inhibitory activity of 61.77%, which is slightly lower than activity after digestion (62.19%). These outcomes suggest that the DPP-IV inhibitory activity of HG60 can be maintained after digestion and absorption. Two novel peptides KAVGDPI and QGVVLRP identified after absorption contain crucial amino acids confirming as DPP-IV inhibitor. |
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| Publish Type | Journal |
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| Publish Year | 2023 |
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| Page Begin | (not set) |
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| Page End | (not set) |
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| Issn | 1226-7708 |
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| Eissn | 2092-6456 |
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| Url | https://www.webofscience.com/wos/woscc/full-record/WOS:000996215400001 |
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| Author | Dr FRISKA CITRA AGUSTIA, S.TP, M.Sc. |
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| File | 121124.pdf |
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