| Abstract | Abstract: Transdermal delivery system is one of the delivery system for Pentagamavunon-0 (PGV-0) toÃÂàavoid the high intensity of first pass metabolism of PGV-0 in peroral route. The purpose of this researchÃÂàwas to optimize the formula of PGV-0 transdermal matrix with a combination of PVP K30 and HPMCÃÂàpolymers.The simplex lattice optimization approach of the transdermal matrix formulas was performed byÃÂàusing Design Expert 7.1.5 software. The visual appearance, weight, thickness, moisture content, moistureÃÂàuptake, folding endurance, drug content, and dissolution efficiency of the release profil of PGV-0 from theÃÂàmatrix for 6 hours were evaluated as responses to determine optimum formula of matrix. The resultÃÂàshowed that a combination of PVP K30 and HPMC polymers had a significant influence on the visualÃÂàappearance, moisture content, and dissolution efficiency of PGV-0. Combination of 1.98% of PVP K30ÃÂàand 4.52% of HPMC as the optimum formula could produce homogeneous and flexible matrix withÃÂàmoisture content of 3.21%. The dissolution efficiency was 9.11%, indicating that 101.93 ÃÂõg of PGV-0 wasÃÂàreleased from the optimum formula during 6 hours.Keywords : Pentagamavunon-0, Transdermal matrix, PVP K30, HPMC |
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