| Abstract | Prevalensi sindrom metabolik (SM) di Indonesia (13,13%) tergolong tinggiÃÂ dengan kecenderungan terus meningkat. Salah satu akibat SM adalahÃÂ disfungsi endotel, sebagai awal penyakit kardiovaskuler yang diinduksi olehÃÂ stres oksidatif dan inflamatif. Penelitian ini bertujuan untuk mengeksplorasiprofil lipid, peroksidasi lipid, dan marker inflamasi pada wanita penderita SMÃÂ di Purwokerto. Sebanyak 30 wanita dengan kadar gula darah diatas normal,ÃÂ obesitas body mass index (BMI) > 25 kg/m2, dan berusia 40-65 tahunÃÂ dilibatkan sebagai responden yang dipilih melalui survei di PoliklinikPenyakit Dalam Rumah Sakit Margono Soekarjo. Kadar kolesterol total,ÃÂ trigliserida, high density lipoprotein, low density lipoprotein, malondialdehid,ÃÂ dan plasma C-reactive protein ditentukan dalam darah responden yangÃÂ mempunyai kadar gula sewaktu > 200 mg/dL. Ditemukan bahwa wanitadengan SM rata-rata berumur 50,4 tahun; BMI 31,89 kg/m2; kadar gulaÃÂ darah 219,4 mg/dL; kolesterol total 216,73 mg/dL; trigliserida 218,13 mg/dL;ÃÂ HDL 46,59 mg/dL; LDL 146,27 mg/dL; MDA 2943,4 pmol/mL; C-RP 7,62ÃÂ mg/L; dan tekanan darah 153/103 mmHg. Hasil ini menunjukkan bahwapenderita SM mengalami dislipidemia disertai dengan status antioksidanÃÂ rendah dan inflamasi.Kata kunci: Wanita sindrom metabolik, profil lipid, lipid peroksida,ÃÂ malondialdehid, C-reactive proteinAbstractPrevalence of metabolic syndrome (MS) in Indonesia (13,13%) is high andÃÂ tends to increase. One of the consequences of MS is endothelial dysfunctionÃÂ leading to cardiovascular disease which is inducted by oxidative stressand inflammation. The aim of the present research is to explore lipid profile,ÃÂ lipid peroxidation, and inflammatory marker level on metabolic syndromeÃÂ women in Purwokerto. Thirty women with blood glucose level greater thanÃÂ normal, body mass index (BMI) > 25 kg/m2, 40-65 years of age were recruitedÃÂ as respondent through selection by a survey in Internal MedicineÃÂ Polyclinic of Margono Soekarjo Hospital in Purwokerto. In respondents withÃÂ blood glucose level > 200 mg/dL, total blood cholesterol level, high densityÃÂ lipoprotein, low density lipoprotein, malondialdehid, and plasma C-reactiveÃÂ protein were determined. It was found that the MS women were 50,4 yearsÃÂ of age; BMI 31,89 kg/m2; blood glucose 219,4 mg/dL; total cholesterolÃÂ 216,73 mg/dL; triglyceride 218,13 mg/dL; HDL 46,59 mg/dL; LDL 146,27mg/dL; MDA 2943,4 pmol/mL; C-RP 7,62 mg/L; and blood pressure 153/103ÃÂ mmHg. It indicates that SM women experience dyslipidemia with low antioxidantÃÂ and inflammation.Key words: Metabolic syndrome women, lipid profile, peroxide lipid, malondialdehid,ÃÂ C-reactive protein |
|---|