| Abstract | Pimpinella pruatjanÃÂ Molkis a local indegineuos plant speciescommonly usedÃÂ ÃÂ aphrodisiac.This studywasÃÂ performedÃÂ to analyze the effect of acute administration ofÃÂ purwoceng (Pimpinella pruatjanÃÂ Molk.)ÃÂ roots ethanol extract to liver and kidney histological damageinÃÂ rats. The study usedÃÂ an experimental approachusing post test only with control group design. Rats were randomly divided into five groups; 3 rats in each group. Group A as a control group received aquadest, group B, C, D, and E were given purwoceng roots ethanol extract dose of 5 mg/kgBW, 50 mg/kgBW, 300 mg/kgBW, and 2000 mg/kgBW respectively.Liver histological damage was assessed by a modification of the Roenigk score, whereaskidney damageÃÂ was by theÃÂ semiquantitative scoring of proximal tubular necrosis. UV test was used to quantify theÃÂ AST and ALT levels,ÃÂ the measurement ofÃÂ blood urea levelsÃÂ was using theÃÂ Urease-GLDH method, andÃÂ Jaffe methodwas usedÃÂ to access the creatinine levels.Kruskal-Wallis test showed that liver and kidney histologicalparameterswere not significantly affected, as wellÃÂ as theblood urea and creatinine levels (p>0.05).Meanwhile,ALTÃÂ levelÃÂ wasonly parameters which showed theÃÂ significantÃÂ test (p <0.05)among groups.ÃÂ Study concluded that theÃÂ liver and kidney histological appearance, AST, blood urea, and creatinine levels in the male albino rat were not significantly affected by acute administration of Purwoceng roots in various dosesbutÃÂ ÃÂ the ALT level was significantly affected |
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