Comparison of Signal-to-Noise, Blank Determination, and Linear Regression Methods for the Estimation of Detection and Quantification Limits for Volatile Organic Compounds by Gas Chromatography
| Publons ID | 4140058 |
|---|---|
| Wos ID | WOS:000273591600027 |
| Doi | |
| Title | Comparison of Signal-to-Noise, Blank Determination, and Linear Regression Methods for the Estimation of Detection and Quantification Limits for Volatile Organic Compounds by Gas Chromatography |
| First Author | |
| Last Author | |
| Authors | Sanagi, MM; Ling, SL; Nasir, Z; Hermawan, D; Ibrahim, WAW; Abu Naim, A; |
| Publish Date | NOV-DEC 2009 |
| Journal Name | JOURNAL OF AOAC INTERNATIONAL |
| Citation | 96 |
| Abstract | LOD and LOQ are two important performance characteristics in method validation. This work compares three methods based on the International Conference on Harmonization and EURACHEM guidelines, namely, signal-to-noise, blank determination, and linear regression, to estimate the LOD and LOQ for volatile organic compounds (VOCs) by experimental methodology using GC. Five VOCs, toluene, ethylbenzene, isopropyl benzene, n-propylbenzene, and styrene, were chosen for the experimental study. The results indicated that the estimated LODs and LOQs were not equivalent and could vary by a factor of 5 to 6 for the different methods. It is, therefore, essential to have a clearly described procedure for estimating the LOD and LOQ during method validation to allow interlaboratory comparisons. |
| Publish Type | Journal |
| Publish Year | 2009 |
| Page Begin | 1833 |
| Page End | 1838 |
| Issn | 1060-3271 |
| Eissn | 1944-7922 |
| Url | https://www.webofscience.com/wos/woscc/full-record/WOS:000273591600027 |
| Author | DADAN HERMAWAN |
| File | 55695.pdf |