Antibiofilm activity of (1)-N-2-methoxybenzyl-1, 10-phenanthrolinium bromide against Candida albicans

Publons ID43332014
Wos IDWOS:000440117300023
Doi10.1016/j.mycmed.2017.12.010
TitleAntibiofilm activity of (1)-<i>N</i>-2-methoxybenzyl-1, 10-phenanthrolinium bromide against <i>Candida albicans</i>
First Author
Last Author
AuthorsNuryastuti, T; Setiawati, S; Ngatidjan, N; Mustofa, M; Jumina, J; Fitriastuti, D; Mardjan, MID;
Publish DateJUN 2018
Journal NameJOURNAL DE MYCOLOGIE MEDICALE
Citation7
AbstractThe therapy for invasive candidiasis related to biofilms infection remains a difficult medical problem. To overcome this problem, efforts have been made to search for novel antibiofilm agents from various sources. This study investigated the in vitro antibiofilm activity of (1)-N-2-methoxybenzyl-1,10-phenanthrolinium bromide (FEN) against Candida albicans. The minimum biofilm inhibitory concentration (MBIC) and minimum biofilm reduction concentration (MBRC) were determined using the MTT (3-(4-5-dimethylthiazol-2-yl)2,5-dyphenyl tetrazolium bromide) reduction assay. Biofilms on surfaces were visualized using scanning electron microscopy (SEM). This new compound inhibited the growth of C. albicans biofilms by 80 % with an MBIC80 range from 0.5-2.0 mu g/mL. The ability of FEN to reduce 50 % of a preformed biofilm was demonstrated by defining a MBRC50 range from 6.25--12.5 mu g/mL. To reduce 80 % of a preformed biofilm required higher concentrations > 200 mu g/mL. In addition, SEM images showed disruption of C. albicans biofilms matrix exposed to FEN. These results indicated that (1)-N-2-methoxybenzyl-1,10-phenanthrolinium bromide has the potential to be developed as a new antibiofilm agent against C. albicans. (C) 2018 Elsevier Masson SAS. All rights reserved.
Publish TypeJournal
Publish Year2018
Page Begin367
Page End373
Issn1156-5233
Eissn1773-0449
Urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:000440117300023
AuthorDr dr. SETIAWATI, S.Ked, M.Sc.
File23466.pdf