Azacoccones F-H, new flavipin-derived alkaloids from an endophytic fungus Epicoccum nigrum MK214079

Publons ID35735687
Wos IDWOS:000580427700044
Doi10.1016/j.fitote.2020.104698
TitleAzacoccones F-H, new flavipin-derived alkaloids from an endophytic fungus Epicoccum nigrum MK214079
First AuthorHarwoko, Harwoko; Lee, Jungho; Hartmann, Rudolf;
Last AuthorProksch, Peter
AuthorsHarwoko, H; Lee, J; Hartmann, R; Mandi, A; Kurtan, T; Muller, WEG; Feldbrugge, M; Kalscheuer, R; Ancheeva, E; Daletos, G; Frank, M; Liu, Z; Proksch, P;
Publish DateOCT 2020
Journal NameFITOTERAPIA
Citation3
AbstractThree new flavipin-derived alkaloids, azacoccones F-H (1-3), along with six known compounds (4-9) were isolated from the endophytic fungus Epicoccum nigrum MK214079 associated with leaves of Salix sp. The structures of the new compounds were established by analysis of their 1D/2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) data. The absolute configuration of azacoccones F-H (1-3) was determined by comparison of experimental electronic circular dichroism (ECD) data with reported ones and biogenetic considerations. Epicocconigrone A (4), epipyrone A (5), and epicoccolide B (6) exhibited moderate antibacterial activity against Staphylococcus aureus ATCC 29213 with minimal inhibitory concentration (MIC) values ranging from 25 to 50 mu M. Furthermore, epipyrone A (5) and epicoccamide A (7) displayed mild antifungal activity against Ustilago maydis AB33 with MIC values of 1.6 and 1.8 mM, respectively. Epicorazine A (8) showed pronounced cytotoxicity against the L5178Y mouse lymphoma cell line with an IC50 value of 1.3 mu M.
Publish TypeJournal
Publish Year2020
Page Begin(not set)
Page End(not set)
Issn0367-326X
Eissn1873-6971
Urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:000580427700044
AuthorDr.rer.nat. Apt HARWOKO, S.Farm, M.Sc.
File16696.pdf