| Publons ID | 4140054 |
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| Wos ID | WOS:000300664000009 |
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| Doi | 10.1002/chir.21990 |
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| Title | Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography |
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| First Author | |
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| Last Author | |
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| Authors | Ibrahim, WAW; Abd Wahib, SM; Hermawan, D; Sanagi, MM; Aboul-Enein, HY; |
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| Publish Date | MAR 2012 |
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| Journal Name | CHIRALITY |
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| Citation | 15 |
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| Abstract | A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) technique has been developed for enantioseparation of vinpocetine using an inexpensive 2-hydroxypropyl-beta-CD (HP-beta-CD) as the chiral selector (CS). The best chiral separation was achieved using 40 mM HP-beta-CD as the CS in 50 mM phosphate buffer (pH 7.0) consisting of 40 mM sodium dodecyl sulfate (SDS) at a separation temperature and separation voltage of 25 degrees C and 25 kV, respectively. To the author's best knowledge, this is the first CD-MEKC study able to successfully separate the four stereoisomer of vinpocetine in separation time of 9.5 min and resolution of 1.043.87. Chirality, 2012. (C) 2012 Wiley Periodicals, Inc. |
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| Publish Type | Journal |
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| Publish Year | 2012 |
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| Page Begin | 252 |
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| Page End | 254 |
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| Issn | 0899-0042 |
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| Eissn | 1520-636X |
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| Url | https://www.webofscience.com/wos/woscc/full-record/WOS:000300664000009 |
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| Author | Prof. DADAN HERMAWAN, S.Si, M.Si, Ph.D |
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| File | 55700.pdf |
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