Mentzer Index Diagnostic Value in Predicting Thalassemia Diagnosis

Publons ID28214471
Wos IDWOS:000481624500004
Doi10.1088/1755-1315/255/1/012004
TitleMentzer Index Diagnostic Value in Predicting Thalassemia Diagnosis
First Author
Last Author
AuthorsSiswandari, W; Rujito, L; Indriani, V; Djatmiko, W;
Publish Date2019
Journal Name1ST INTERNATIONAL CONFERENCE ON LIFE AND APPLIED SCIENCES FOR SUSTAINABLE RURAL DEVELOPMENT
Citation2
AbstractThalassemia diagnosis requires gen examination using Polymerase Chain Reaction (PCR) device or hemoglobin (Hb) electrophoresis using electrophoresis or High Performance Liquid Chromatography (HPLC) device which is only available in certain hospitals. Therefore, it is important to develop easily examined parameters which are useful to assess thalassemia carrier diagnosis. This study aims at figuring out the diagnostic value of Mentzer Index in predicting beta-thalassemia carrier compared to the results of HB electrophoresis examination. Data were taken from 37 anemia patients at Prof. Dr. Margono Soekarjo Regional Public Hospital in Purwokerto who underwent Hb electrophoresis examination using electrophoresis instrument and routine blood count. Furthermore, Mentzer Index was calculated, odds ratio (OR) was analyzed, and diagnostic values were compared to the results of Hb electrophoresis. Mentzer index OR value was 2.4 (0.5 - 11.5, CI95%). Mentzer Index sensitivity (Sn) was 0.36 with specificity (Sp) at 0.81, positive predictive value (PPV) at 0.44 and negative predictive value (NPV) at 0.75. Mentzer index could be used to predict the diagnosis of beta-thalassemia carrier.
Publish TypeBook in series
Publish Year2019
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Issn1755-1307
Eissn
Urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:000481624500004
AuthorDr Dr dr. VM WAHYU SISWANDARI, S.Ked, Sp.P.K, M.Si.Med
File23904.pdf